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Rain Showers Splash Pond Toddler Water Table,Toys & Games
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Is Your Volvo XC90 Displaying Anti-Skid Service Required Alert Here's Why
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How Your Body Metabolizes Medications
⏲ 1:42 👁 10K
HEIGHTENED SECURITY AT POSGH AFTER SHOOTING
⏲ 4:41 👁 700K
Nvidia's 10-for-1 Stock Split Nears, Shares to Begin Trading at Lower Price
⏲ 0:33 👁 260K
Populist Campaigner Nigel Farage Says He Will Run in the U.K. Election
⏲ 1:44 👁 200K
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_rain-showers-splash-pond-toddler-water-table-toys-amp-games.jpg "Design: PlaySet<br/>OUTDOOR FUN: Water table for toddlers to splash, pour, and explore, interactive playtime experience designed with rain showers to spark imaginative play, can also be filled with sand<br/>SPLASH TOYS: 13-piece toy set, duck and tropical fish squish toys, watch as the waterfall flows down the maze-like spinners, activating teeter-totter, teaching cause and effect STEM play<br/>FUN FOR ALL KIDS: Large footprint lets several kids play together, easy accessible, encouraging social and sharing skills, basin holds up to 5 gallons, dimensions 32\")
_is-your-volvo-xc90-displaying-anti-skid-service-required-alert-here39s-why.jpg "We know how disconcerting the appearance of \")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.jpg "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_heightened-security-at-posgh-after-shooting.jpg "Three people are now warded at the Port of Spain General Hospital following two related shooting incidents - the first in Gonzales and the second, at the Accident and Emergency Unit of the Hospital.<br/><br/><br/>While security measures are to be ramped up with immediate effect, hospital officials point out that the facility is a hospital, not a prison. Rynessa Cutting reports.")
_nvidia39s-10-for-1-stock-split-nears-shares-to-begin-trading-at-lower-price.jpg "Nvidia announced a 10-for-1 stock split in May, which will take effect after trading closes on June 9th. Investors who own Nvidia stock at the end of trading on Thursday will receive 9 additional shares for every 1 share held. The stock price will be adjusted to reflect the split, with trading of the split shares beginning on Monday at the new lower price. Nvidia's market cap surpassed $3 trillion in part due to news of the large stock and dividend payouts and a major order from Tesla.")
_populist-campaigner-nigel-farage-says-he-will-run-in-the-u-k-election.jpg "Pro-Brexit, anti-immigration campaigner Nigel Farage stepped back into front-line British politics on Monday, announcing he will take the helm of the right-wing party Reform U.K. and run for Parliament in the July 4 election.")
_rain-showers-splash-pond-toddler-water-table-toys-amp-games.webp "Design: PlaySet<br/>OUTDOOR FUN: Water table for toddlers to splash, pour, and explore, interactive playtime experience designed with rain showers to spark imaginative play, can also be filled with sand<br/>SPLASH TOYS: 13-piece toy set, duck and tropical fish squish toys, watch as the waterfall flows down the maze-like spinners, activating teeter-totter, teaching cause and effect STEM play<br/>FUN FOR ALL KIDS: Large footprint lets several kids play together, easy accessible, encouraging social and sharing skills, basin holds up to 5 gallons, dimensions 32\")
_is-your-volvo-xc90-displaying-anti-skid-service-required-alert-here39s-why.webp "We know how disconcerting the appearance of \")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_heightened-security-at-posgh-after-shooting.webp "Three people are now warded at the Port of Spain General Hospital following two related shooting incidents - the first in Gonzales and the second, at the Accident and Emergency Unit of the Hospital.<br/><br/><br/>While security measures are to be ramped up with immediate effect, hospital officials point out that the facility is a hospital, not a prison. Rynessa Cutting reports.")
_nvidia39s-10-for-1-stock-split-nears-shares-to-begin-trading-at-lower-price.webp "Nvidia announced a 10-for-1 stock split in May, which will take effect after trading closes on June 9th. Investors who own Nvidia stock at the end of trading on Thursday will receive 9 additional shares for every 1 share held. The stock price will be adjusted to reflect the split, with trading of the split shares beginning on Monday at the new lower price. Nvidia's market cap surpassed $3 trillion in part due to news of the large stock and dividend payouts and a major order from Tesla.")
_populist-campaigner-nigel-farage-says-he-will-run-in-the-u-k-election.webp "Pro-Brexit, anti-immigration campaigner Nigel Farage stepped back into front-line British politics on Monday, announcing he will take the helm of the right-wing party Reform U.K. and run for Parliament in the July 4 election.")
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